Publications of Prof. Dr. Wolfgang HolzerProf. Holzer (co-)authors more than 200 scientific articles, reviews, patents, and book chapters. His current h-index is 33 (according to Web of Science) and 33 (according to Scopus). [November 2022] period 1985—1989
period 1990—1999
period 2000—2009
period 2010—2019
period 2020—
most recent
1985–1989
1. Binder, Dieter; Noe, Christian R.; Holzer, Wolfgang; Rosenwirth, Brigitte. Thiophene as a structural element of physiologically active substances, XII. Thiophene analogs of antiviral chalcones. Archiv der Pharmazie (1985), 318(1), 48-59. doi:10.1002/ardp.19853180111
2. Binder, Dieter; Noe, Christian R.; Holzer, Wolfgang; Rosenwirth, Brigitte. Thiophene as a structural element of physiologically active substances, XIII. Thiophene analogs of antiviral flavans. Archiv der Pharmazie (Weinheim, Germany) (1985), 318(1), 70-8. doi:10.1002/ardp.19853180113
3. Heinisch, Gottfried; Holzer, Wolfgang; Nawwar, Galal A. M. Pyridazines. XXVI. A novel synthesis of pyrano[2,3-d]pyridazines. Journal of Heterocyclic Chemistry (1986), 23(1), 93-6. doi:10.1002/jhet.5570230119
4. Heinisch, Gottfried; Holzer, Wolfgang; Nawwar, Galal A. M. Reactions of 4,5-unsaturated 3-oxoalkanenitriles with Michael acceptors. Monatshefte fuer Chemie (1986), 117(2), 247-53. doi:10.1007/BF00809444
5. Heinisch, Gottfried; Holzer, Wolfgang; Voellenkle, Horst. The structure of the reaction product from the reaction of 2-hydroximino-3-oxo-5-phenyl-4-pentenenitrile with ethyl cyanoacetate. Monatshefte fuer Chemie (1987), 118(3), 409-13. doi:10.1007/BF00809952
6. Binder, Dieter; Noe, Christian R.; Holzer, Wolfgang; Baumann, Karl. Thiophene as a structural element of physiologically active compounds. XVI. Thienoisoxazoles by substitution at the oxime nitrogen. Archiv der Pharmazie (Weinheim, Germany) (1987), 320(9), 837-43. doi:10.1002/ardp.19873200911
7. Heinisch, Gottfried; Holzer, Wolfgang; Huber, Thierry. Pyrazole chemistry. I. Efficient syntheses of aryl or benzyl 4-pyrazolyl ketones and carbinols. Archiv der Pharmazie (Weinheim, Germany) (1987), 320(12), 1267-72. doi:10.1002/ardp.198700044
8. Heinisch, Gottfried; Holzer, Wolfgang; Obala, Claudia. Pyrazoles II. The chemistry of pyrazolylalkynes. Monatshefte fuer Chemie (1988), 119(2), 253-62. doi:10.1007/BF00809599
9. Binder, Dieter; Noe, Christian R.; Baumann, Karl; Holzer, Wolfgang. Thiophene as a structural element of physiologically active compounds. XVII. Thienoisoxazoles via nucleophilic substitution. Archiv der Pharmazie (Weinheim, Germany) (1988), 321(7), 391-5. doi:10.1002/ardp.19883210704
10. Heinisch, Gottfried; Holzer, Wolfgang. Pyrazoles. 3. N-1 Protected 4-substituted pyrazoles - synthesis and NMR investigation. Heterocycles (1988), 27(10), 2443-57. doi:10.3987/COM-88-4681
11. Easmon, J.; Heinisch, G.; Holzer, W.; Rosenwirth, B. Synthesis and antiviral activity of thiosemicarbazone derivatives of pyridazinecarbaldehydes and alkyl pyridazinyl ketones. Arzneimittel-Forschung (1989), 39(10), 1196-201.
12. Holzer, W.; Von Philipsborn, W. Inter- and intramolecular hydrogen bonding effects on geminal nitrogen-15, proton spin coupling and nitrogen-15 chemical shifts in pyridine derivatives. Magnetic Resonance in Chemistry (1989), 27(6), 511-14. doi:10.1002/mrc.1260270602
13. Easmon, Johnny; Heinisch, Gottfried; Holzer, Wolfgang. Pyridazines. 47. The configuration of novel thiosemicarbazone derivatives of pyridazinecarboxaldehydes and alkyl pyridazinyl ketones. Heterocycles (1989), 29(7), 1399-408. doi:10.3987/COM-89-5012
1990–1999
14. Heinisch, Gottfried; Holzer, Wolfgang. Convenient and rapid determination of the configuration of aldoximes and ketoximes by means of NOE difference spectroscopy. Tetrahedron Letters (1990), 31(22), 3109-12. doi:10.1016/S0040-4039(00)94707-5
15. Heinisch, Gottfried; Holzer, Wolfgang; Pock, Sabine. Pyrazole chemistry. Part 4. Directed lithiation of 4-bromo-1-(phenylsulfonyl)pyrazole: a convenient approach to vicinally disubstituted pyrazoles. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1990), (7), 1829-34. doi:10.1039/P19900001829
16. Binder, Dieter; Noe, Christian R.; Holzer, Wolfgang. Thiophene as a structural element of physiologically active compounds. XVIII. A thiophene analog of propafenone. Archiv der Pharmazie (Weinheim, Germany) (1990), 323(11), 919-21. doi:10.1002/ardp.19903231108
17. Dostal, Wolfgang; Heinisch, Gottfried; Holzer, Wolfgang; Perhauc, Ingrid; Zheng, Changtu. Pyridazines. LI. On the Reactivity of Pyridazinecarbaldehydes towards Selected Active-Hydrogen Compounds. Journal of Heterocyclic Chemistry (1990), 27(5), 1313-21. doi:10.1002/jhet.5570270526
18. Heinisch, Gottfried; Holzer, Wolfgang. On the application of homonuclear NOE difference spectroscopy as a convenient tool for configurational assignment of compounds with a carbon-nitrogen double bond. Monatshefte fuer Chemie (1990), 121(10), 837-46. doi:10.1007/BF00808377
19. Holzer, Wolfgang. NOE difference spectroscopy as a versatile tool for spectral and structural assignment in various N-1 substituted pyrazoles. Tetrahedron (1991), 47(8), 1393-8. doi:10.1016/S0040-4020(01)86415-2
20. Heinisch, Gottfried; Holzer, Wolfgang. Pyridazines. 53. Carbon-13 nuclear magnetic resonance spectra of 3,6-disubstituted pyridazines. Canadian Journal of Chemistry (1991), 69(6), 972-7. doi:10.1139/v91-142
21. Holzer, Wolfgang. Spectral and structural assignments with various N-substituted 1,2,4-triazoles: NOE difference spectroscopy as a powerful tool. Tetrahedron (1991), 47(29), 5471-80. doi:10.1016/S0040-4020(01)80980-7
22. Heinisch, Gottfried; Hollub, Christian; Holzer, Wolfgang. Pyrazoles. 5. Novel pyrazole analogs of flavanone, flavone and flavane. Journal of Heterocyclic Chemistry (1991), 28(4), 1047-50. doi:10.1002/jhet.5570280436
23. Hahn, Marianne; Heinisch, Gottfried; Holzer, Wolfgang; Schwarz, Helga. Pyrazoles. 6. Synthesis of novel heteroaryl 4-pyrazolyl ketones. Journal of Heterocyclic Chemistry (1991), 28(5), 1189-92. doi:10.1002/jhet.5570280505
24. Holzer, Wolfgang. On the application of nuclear Overhauser effect difference spectroscopy for spectral and structural assignments with substituted 1,2,3-triazoles. Tetrahedron (1991), 47(47), 9783-92. doi:10.1016/S0040-4020(01)80718-3
25. Heinisch, Gottfried; Holzer, Wolfgang; Huber, Thierry. Pyridazines. LVIII. 1-Phenyl-1-pyridazinyl-2-substituted ethenes. Synthesis and configuration. Monatshefte fuer Chemie (1991), 122(12), 1055-61. doi:10.1007/BF00811114
26. Heinisch, Gottfried; Holzer, Wolfgang. Configurational assignment of aryl heteroaryl ketoximes by means of homonuclear NOE difference spectroscopy. Collection of Czechoslovak Chemical Communications (1991), 56(11A), 2251-7. doi:10.1135/cccc19912251
27. Fugina, Natalie; Holzer, Wolfgang; Wasicky, Michael. The [2-(trimethylsilyl)ethoxy]methyl function as a suitable N-1-protecting group in lithiation reactions with pyrazoles and 1,2,4-triazoles. Heterocycles (1992), 34(2), 303-14. doi:10.3987/COM-91-5913
28. Easmon, Johnny; Heinisch, Gottfried; Holzer, Wolfgang; Rosenwirth, Brigitte. Pyridazines. 63. Novel thiosemicarbazones derived from formyl- and acyldiazines: synthesis, effects on cell proliferation, and synergism with antiviral agents. Journal of Medicinal Chemistry (1992), 35(17), 3288-96. doi:10.1021/jm00095a027
29. Holzer, Wolfgang. Determination of the stereochemistry of chemotherapeutics derived from 5-nitrofurfural: NOE difference spectroscopy as a simple and reliable method. Archiv der Pharmazie (Weinheim, Germany) (1992), 325(12), 769-72. doi:10.1002/ardp.19923251205
30. Holzer, Wolfgang; Jaeger, Christine. On the discrimination of tetrazole regioisomers by NOE difference spectroscopy. Monatshefte fuer Chemie (1992), 123(11), 1027-36. doi:10.1007/BF00810934
31. Holzer, Wolfgang; Gyorgydeak, Zoltan. The structure of guanylhydrazones derived from aromatic aldehydes. Monatshefte fuer Chemie (1992), 123(12), 1163-73. doi:10.1007/BF00808279
32. Holzer, Wolfgang; Ruso, Karina. Functionalization of 1,2,3-triazole via lithiation of 1-[2-(trimethylsilyl)ethoxy]methyl-1H-1,2,3-triazole. Journal of Heterocyclic Chemistry (1992), 29(5), 1203-7. doi:10.1002/jhet.5570290526
33. Rykowski, Andrzej; Guzik, Eliza; Makosza, Mieczyslaw; Holzer, Wolfgang. Configurational assignments of oximes derived from 5-formyl and 5-acyl-1,2,4-triazines. Journal of Heterocyclic Chemistry (1993), 30(2), 413-18. doi:10.1002/jhet.5570300222
34. Holzer, Wolfgang; Seiringer, Gertrud. N1 Substituted ethyl 4-pyrazolecarboxylates: synthesis and spectroscopic investigations. Journal of Heterocyclic Chemistry (1993), 30(4), 865-72. doi:10.1002/jhet.5570300404
35. Easmon, Johnny; Heinisch, Gottfried; Holzer, Wolfgang. Pyridazines. Part 66. The stereochemistry of novel biologically active diazine-derived thiosemicarbazones. Scientia Pharmaceutica (1993), 61(1), 3-10.
36. Holzer, Wolfgang; Jager, Christine; Slatin, Christoph. N-substituted bromopyrazoles: synthesis and 13C NMR study. Heterocycles (1994), 38(11), 2433-48. doi:10.3987/COM-94-6860
37. Holzer, W.; Schmid, E.; Slatin, C. The reaction of diethyl 3,4-dihydroxythiophene-2,5-dicarboxylate with 1,2-dibromoethane. Monatshefte fuer Chemie (1994), 125(11), 1287-91. doi:10.1007/BF00813816
38. Holzer, Wolfgang; Poecher, Ingrid. Synthesis and 13C NMR study of some N-substituted 4-iodo- and 3,4-diiodopyrazoles. Journal of Heterocyclic Chemistry (1995), 32(1), 189-94. doi:10.1002/jhet.5570320131
39. Easmon, Johnny; Heinisch, Gottfried; Holzer, Wolfgang; Matuszczak, Barbara. Pyridazines. LXXII: On the synthesis of azinium and diazinium compounds structurally related to pyridazomycin. Archiv der Pharmazie (Weinheim, Germany) (1995), 328(4), 307-12. doi:10.1002/ardp.19953280403
40. Easmon, Johnny; Heinisch, Gottfried; Holzer, Wolfgang; Matuszczak, Barbara. Preparation of amino- and carboxy-protected L-a-amino-w-iodo carboxylic acids. Archiv der Pharmazie (Weinheim, Germany) (1995), 328(4), 367-70. doi:10.1002/ardp.19953280414
41. Gyoergydeak, Z.; Holzer, W.; Kunz, R. W.; Linden, A. 1,4,-Diacyl-3-acylamino-5-aryl-4,5-dihydro-1H-1,2,4-triazoles: ring closure products of aromatic carbaldehyde (diaminomethylene)hydrazones with acylating agents. Monatshefte fuer Chemie (1995), 126(6/7), 733-46. doi:10.1007/BF00807164
42. Holzer, Wolfgang; Schmid, Eva. NMR spectroscopic investigations with ethyl 1-(hetero)aryl-5-hydroxy-1H-pyrazole-4-carboxylates. Journal of Heterocyclic Chemistry (1995), 32(4), 1341-9. doi:10.1002/jhet.5570320440
43. Holzer, Wolfgang; Gruber, Heidi. N1-Substituted 3,5-dimethoxy-4-halogeno-1H-pyrazoles: synthesis and NMR study. Journal of Heterocyclic Chemistry (1995), 32(4), 1351-4. doi:10.1002/jhet.5570320441
44. Franz, Claudia; Heinisch, Gottfried; Holzer, Wolfgang; Mereiter, Kurt; Strobl, Barbara; Zheng, Changtu. Reaction products of 1,3-indandione with heteroaromatic carbaldehydes: synthesis, structure and NMR investigations. Heterocycles (1995), 41(11), 2527-51. doi:10.3987/COM-95-7203
45. Heinisch, Gottfried; Holzer, Wolfgang; Langer, Thierry; Lukavsky, Peter. Aryl diazinyl ketoximes: synthesis and configurational assignment. Heterocycles (1996), 43(1), 151-72. doi:10.3987/COM-95-7248
46. Easmon, J.; Heinisch, G.; Holzer, W.; Matuszczak, Barbara. on the synthesis of pyridazomycin congeners. Part 2. L-a-Amino acids bearing a terminal azinium or diazinium system. Pharmazie (1996), 51(2), 76-83.
47. Easmon, J.; Heinisch, G.; Holzer, W. Arylsulfonylhydrazones derived from 2-acetylpyridine N-oxide and 3-acetylpyridazine N-oxide. Synthesis and comparison of antiproliferative activity. Scientia Pharmaceutica (1996), 64(1), 37-49.
48. Holzer, Wolfgang; Gyoergydeak, Zoltan. NMR spectroscopic investigation of isatin guanylhydrazones. Journal of Heterocyclic Chemistry (1996), 33(3), 675-680. doi:10.1002/jhet.5570330326
49. Heinisch, Gottfried; Holzer, Wolfgang; Mereiter, Kurt; Strobl, Barbara; Zheng, Changtu. Formation of spiro-lactols upon reaction of ninhydrin with methyldiazines. Heterocycles (1996), 43(8), 1665-1679. doi:10.3987/COM-96-7488
50. Heinisch, Gottfried; Holzer, Wolfgang; Kunz, Friedbert; Langer, Thierry; Lukavsky, Peter; Pechlaner, Christoph; Weissenberger, Hans. On the Bioisosteric Potential of Diazines: Diazine Analogs of the Combined Thromboxane A2 Receptor Antagonist and Synthetase Inhibitor Ridogrel. Journal of Medicinal Chemistry (1996), 39(20), 4058-4064. doi:10.1021/jm960341g
51. Heinisch, G.; Holzer, W.; Langer, T.; Lukavsky, P. Stereochemistry of novel antithrombotic aryl diazinyl ketoxime ethers. Scientia Pharmaceutica (1996), 64(3/4), 429-435.
52. Holzer, Wolfgang; Plagens, Brigitte. Methylation of pyrazolones. Scientia Pharmaceutica (1996), 64(3/4), 455-462.
53. Spreitzer, Helmut; Holzer, Wolfgang; Fulep, Gunther; Puschmann, Christiane. N-Substituted 5,5-dimethyl-2,5-dihydro-4H-isoindol-4-ones: synthesis and NMR investigation. Heterocycles (1996), 43(9), 1911-1922. doi:10.3987/COM-96-7510
54. Spreitzer, Helmut; Pichler, Andrea; Holzer, Wolfgang; Toth, Irene; Zuchart, Bettina. Synthesis and odor of chiral partial structures of khusimone. Part 1. Helvetica Chimica Acta (1997), 80(1), 139-145. doi:10.1002/hlca.19970800114
55. Holzer, Wolfgang; Plagens, Brigitte; Lorenz, Karin. Alkylation of pyrazolones via the Mitsunobu reaction. Heterocycles (1997), 45(2), 309-314. doi:10.3987/COM-96-7657
56. Pippich, Susanne; Bartsch, Herbert; Holzer, Wolfgang. Studies on the chemistry of O,N- and S,N-containing heterocycles. 17. Studies on ring opening reactions of b-lactams. Tetrahedron (1997), 53(25), 8439-8446. doi:10.1016/S0040-4020(97)00563-2
57. Gyorgydeak, Zoltan; Holzer, Wolfgang; Thiem, Joachim. Heterocyclic compounds from sugars. XVI. Cyclization reactions of N1-(glycopyranosylamino)guanidines. Carbohydrate Research (1997), 302(3-4), 229-235. doi:10.1016/S0008-6215(97)00116-X
58. Spreitzer, Helmut; Pichler, Andrea; Holzer, Wolfgang; Shahabi, Manocher. Synthesis and odor of chiral partial structures of khusimone. Part 2. Helvetica Chimica Acta (1997), 80(6), 1857-1864. doi:10.1002/hlca.19970800609
59. Spreitzer, Helmut; Holzer, Wolfgang; Puschmann, Christiane; Pichler, Andrea; Kogard, Angelika; Tschetschkowitsch, Klaus; Heinze, Tatjana; Bauer, Sabina; Shabaz, Nejati. Synthesis and NMR-investigation of annulated pyrrole derivatives. Heterocycles (1997), 45(10), 1989-1997. doi:10.3987/COM-97-7877
60. Spreitzer, Helmut; Pichler, Andrea; Holzer, Wolfgang; Schlager, Claudia. Synthesis and odor of chiral partial structures of khusimone. Part 3. Helvetica Chimica Acta (1998), 81(1), 40-45. doi:10.1002/hlca.19980810105
61. Gyorgydeak, Zoltan; Holzer, Wolfgang. Acylation of guanylhydrazones derived from cyclic ketones: synthesis of 3-acylamino-1-cycloalkenyl-5-methyl-1H-1,2,4-triazoles. Heterocycles (1998), 48(7), 1395-1406. doi:10.3987/COM-98-8162
62. Chiba, Peter; Holzer, Wolfgang; Landau, Marion; Bechmann, Gerhard; Lorenz, Karin; Plagens, Brigitte; Hitzler, Manuela; Richter, Elisabeth; Ecker, Gerhard. Substituted 4-Acylpyrazoles and 4-Acylpyrazolones: Synthesis and Multidrug Resistance-Modulating Activity. Journal of Medicinal Chemistry (1998), 41(21), 4001-4011. doi:10.1021/jm980121y
63. Kiec-Kononowicz, Katarzyna; Szymanska, E.; Motyl, M.; Holzer, W.; Bialecka, A.; Kasprowicz, A. Synthesis, spectral, and antimicrobial properties of 5-chloroarylidene aromatic derivatives of imidazolin-4-one. Pharmazie (1998), 53(10), 680-684.
64. Spreitzer, Helmut; Piringer, Iris; Holzer, Wolfgang; Widhalm, Michael. Structure/odor relationships of (-)- and (+)-b-vetivone, and their demethyl derivatives. Helvetica Chimica Acta (1998), 81(12), 2292-2299. doi:10.1002/(SICI)1522-2675(19981216)81:12<2292::AID-HLCA2292>3.0.CO;2-K
65. Spreitzer, Helmut; Piringer, Iris; Pichler, Andrea; Holzer, Wolfgang; Schreder, Petra; Widhalm, Michael. Synthesis and odor of chiral partial structures of b-vetivone. I. Chirality (1999), 11(1), 14-20. doi:10.1002/(SICI)1520-636X(1999)11:1<14::AID-CHIR3>3.0.CO;2-7
66. Spreitzer, Helmut; Piringer, Iris; Pichler, Andrea; Holzer, Wolfgang; Ruzicka, Jana; Widhalm, Michael. Synthesis and odor of chiral partial structures of b-Vetivone, part 2. Chirality (1999), 11(2), 133-138. doi:10.1002/(SICI)1520-636X(1999)11:2<133::AID-CHIR9>3.0.CO;2-E
67. Holzer, Wolfgang; Mereiter, Kurt; Plagens, Brigitte. 4-acyl-5-methyl-2-phenylpyrazolones: NMR and X-ray structure investigations. Heterocycles (1999), 50(2), 799-818. doi:10.3987/COM-98-S(H)74
68. Tolmachev, Andrei A.; Dovgopoly, Sergei I.; Kostyuk, Aleksandr N.; Kozlov, Ernest S.; Pushechnikov, Aleksei O.; Holzer, Wolfgang. Synthesis and characterization of 4,5-dihydro-1H-pyrazolo[3,4b][1,4]azaphosphinines. Heteroatom Chemistry (1999), 10(5), 391-398. doi:10.1002/(SICI)1098-1071(1999)10:5<391::AID-HC9>3.0.CO;2-M
69. Kiec-Kononowicz, Katarzyna; Holzer, Wolfgang; Mereiter, Kurt. Imidazoquinazolinediones - new results. Heterocycles (1999), 51(7), 1597-1608. doi:10.3987/COM-99-8558
70. Gyorgydeak, Zoltan; Holzer, Wolfgang; Mereiter, Kurt. Guanylhydrazones of (hetero)aryl methyl ketones. Structure and reaction with acetic anhydride. Monatshefte fuer Chemie (1999), 130(7), 899-913. doi:10.1007/PL00010271
2000—2009
71. Annibali, Danilo; Ecker, Gerhard; Fleischhacker, Wilhelm; Helml, Thomas; Holzer, Wolfgang; Noe, Christian R. A method for the synthesis of 2,3-disubstituted 2,3-dihydrobenzofurans. Monatshefte fuer Chemie (2000), 131(4), 375-382. doi:10.1007/s007060050318
72. Spreitzer, Helmut; Pichler, Andrea; Holzer, Wolfgang; Kratzel, Martin; Slanz, Rita; Koulouri, Alexandra; Krenn, Petra; Parrer, Ulrike; Szieber, Petra. Synthesis of azanaphthoquinone annelated pyrroles. Heterocycles (2001), 54(1), 111-121. doi:10.3987/COM-98-8401
73. Kovacs, L.; Osz, E.; Domokos, V.; Holzer, W.; Gyorgydeak, Z. An easy access to anomeric glycosyl amides and imines (Schiff bases) via transformation of glycopyranosyl trimethylphosphinimides. Tetrahedron (2001), 57(21), 4609-4621. doi:10.1016/S0040-4020(01)00380-5
74. Easmon, Johnny; Puerstinger, Gerhard; Heinisch, Gottfried; Roth, Thomas; Fiebig, Heinz H.; Holzer, Wolfgang; Jaeger, Walter; Jenny, Marcel; Hofmann, Johann. Synthesis, Cytotoxicity, and Antitumor Activity of Copper(II) and Iron(II) Complexes of 4N-Azabicyclo[3.2.2]nonane Thiosemicarbazones Derived from Acyl Diazines. Journal of Medicinal Chemistry (2001), 44(13), 2164-2171. doi:10.1021/jm000979z
75. Holzer, Wolfgang. Unambiguous assignment of the 1H- and 13C-NMR spectra of propafenone and a thiophene analog. Molecules (2001), 6(10), 796-802. doi:10.3390/61000796
76. Ecker, Gerhard F.; Csaszar, Edina; Kopp, Stephan; Plagens, Brigitte; Holzer, Wolfgang; Ernst, Wolfgang; Chiba, Peter. Identification of ligand-binding regions of P-glycoprotein by activated-pharmacophore photoaffinity labeling and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry. Molecular Pharmacology (2002), 61(3), 637-648. doi:10.1124/mol.61.3.637
77. Akinchan, N. T.; Drozdzewski, P. M.; Holzer, W. Syntheses and spectroscopic studies on zinc(II) and mercury(II) complexes of isatin-3-thiosemicarbazone. Journal of Molecular Structure (2002), 641(1), 17-22. doi:10.1016/S0022-2860(02)00134-5
78. Jager, Christine; Laggner, Christian; Mereiter, Kurt; Holzer, Wolfgang. A ring-fission/C-C bond cleavage reaction with an N-alkyl-N-methyl-N-[(5-phenyl-1,2,4-oxadiazol-3-yl)methyl]amine. Tetrahedron (2002), 58(52), 10417-10422. doi:10.1016/S0040-4020(02)01410-2
79. Holzer, Wolfgang; Hahn, Katharina; Brehmer, Thomas; Claramunt, Rosa M.; Perez-Torralba, Marta. The structure of 4-benzoyl-5-methyl-2-phenylpyrazol-3-one oxime and its methyl derivatives. European Journal of Organic Chemistry (2003), (7), 1209-1219. doi:10.1002/ejoc.200390175
80. Holzer, Wolfgang; Hahn, Katharina. Synthesis of substituted 3-phenyl-6H-pyrazolo[4,3-d]isoxazoles from corresponding 4-benzoyl-5-hydroxypyrazoles. Journal of Heterocyclic Chemistry (2003), 40(2), 303-308. doi:10.1002/jhet.5570400216
81. Holzer, Wolfgang; Claramunt, Rosa M.; Perez-Torralba, Marta; Guggi, Davide; Brehmer, Thomas H. Spiro-Fused (C2)-Azirino-(C4)-pyrazolones, a New Heterocyclic System. Synthesis, Spectroscopic Studies and X-ray Structure Analysis. Journal of Organic Chemistry (2003), 68(21), 7943-7950. doi:10.1021/jo030131t
82. Holzer, Wolfgang; Krca, Ingrid. New 1-substituted 4-cinnamoyl-5-hydroxypyrazoles and precursors thereof: Synthesis, ring closure reactions and NMR-spectroscopic investigations. Heterocycles (2003), 60(10), 2323-2342. doi:10.3987/COM-03-9857
83. Gyoergydeak, Zoltan; Szabo, Gyoergy; Holzer, Wolfgang. 2-Amino-4-aryl-1-arylideneaminoimidazoles and Acylation Products: A Multinuclear (1H, 13C, 15N) NMR Study. Monatshefte fuer Chemie (2004), 135(2), 173-184. doi:10.1007/s00706-003-0104-3
84. Haider, N.; Holzer, W. Product class 8: pyridazines. Science of Synthesis (2004), 16, 125-249.
85. Haider, N.; Holzer, W. Product class 9: cinnolines. Science of Synthesis (2004), 16, 251-313.
86. Haider, N.; Holzer, W. Product class 10: phthalazines. Science of Synthesis (2004), 16, 315-372.
87. Haider, N.; Holzer, W. Product class 11: pyridazino[1,2-a]pyridazines. Science of Synthesis (2004), 16, 373-378.
88. Holzer, Wolfgang; Hallak, Linda. Synthesis and NMR spectroscopic investigations with 3-amino-, 3-hydroxy-, and 3-methoxy-4-acyl-1-phenyl-2-pyrazolin-5-ones. Heterocycles (2004), 63(6), 1311-1334. doi:10.3987/COM-04-10046
89. Holzer, Wolfgang; Kautsch, Constanze; Laggner, Christian; Claramunt, Rosa M.; Perez-Torralba, Marta; Alkorta, Ibon; Elguero, Jose. On the tautomerism of pyrazolones: the geminal 2J[pyrazole C-4,H-3(5)] spin coupling constant as a diagnostic tool. Tetrahedron (2004), 60(32), 6791-6805. doi:10.1016/j.tet.2004.06.039
90. Holzer, Wolfgang; Brandstatter, Bettina; Jager, Christine; Kaun, Michael; Langer, Thierry; Bowen, Wayne D. N-(3,4-dichlorobenzyl)azoles - investigations regarding synthesis, NMR-spectroscopy and affinity towards sigma-1 and sigma-2 receptors. Scientia Pharmaceutica (2004), 72(3), 197-211. doi:10.3797/scipharm.aut-04-16
91. Eller, Gernot A.; Holzer, Wolfgang. The 4-methoxybenzyl (PMB) function as a versatile protecting group in the synthesis of N-unsubstituted pyrazolones. Heterocycles (2004), 63(11), 2537-2555. doi:10.3987/COM-04-10190
92. Dal Piaz, V.; Graziano, A.; Haider, N.; Holzer, W. Synthesis and complete 1H, 13C and 15N NMR assignment of substituted isoxazolo[3,4-d]pyridazin-7(6H)-ones. Magnetic Resonance in Chemistry (2005), 43(3), 240-245. doi:10.1002/mrc.1528
93. Becker, Wilfried; Eller, Gernot A.; Holzer, Wolfgang. A Simple Synthesis of 6-Phenylpyrano[2,3-c]pyrazol4(1H)-ones. Synthesis (2005), (15), 2583-2589. doi:10.1055/s-2005-872078
94. Singh, Palwinder; Paul, Kamaldeep; Holzer, Wolfgang. Synthesis of 5-acyl-6-[2-hydroxy-3-(amino)propylamino]-1,3-dialkyl-1H-pyrimidine-2,4-diones. Organic & Biomolecular Chemistry (2005), 3, 3958-3965. doi:10.1039/b509775d
95. Singh, Palwinder; Paul, Kamaldeep; Holzer, Wolfgang. Multi drug resistance: an obstacle to the successful chemotherapy of cancer - its mechanism and remedies via MDR modulators. National Academy Science Letters (India) (2005), 28(11 & 12), 365-372.
96. Eller, Gernot A.; Holzer, Wolfgang. A one-step synthesis of pyrazolone. Molbank (2006), M464/1-3. doi:10.3390/M464
97. Dumciute, Joana; Martynaitis, Vytas; Holzer, Wolfgang; Mangelinckx, Sven; De Kimpe, Norbert; Sackus, Algirdas. Synthesis and ring transformations of 1-amino-1,2,3,9a-tetrahydroimidazo[1,2-a]indol-2(9H)-ones. Tetrahedron (2006), 62(14), 3309-3319. doi:10.1016/j.tet.2006.01.054
98. Eller, Gernot A.; Holzer, Wolfgang. First synthesis of 3-acetyl-2-aminothiophenes using the gewald reaction. Molecules (2006), 11(5), 371-376. doi:10.3390/11050371
99. Singh, Palwinder; Paul, Kamaldeep; Holzer, Wolfgang. Synthesis of pyrazole-based hybrid molecules: search for potent multidrug resistance modulators. Bioorganic & Medicinal Chemistry (2006), 14(14), 5061-5071. doi:10.1016/j.bmc.2006.02.046
100. Hoefinghoff, J.; Buchbauer, G.; Holzer, W.; Wolschann, P. Syntheses and odor of “bulky group”-modified sandalwood odorants: isophorono-β-santalol analogues. European Journal of Medicinal Chemistry (2006), 41(8), 905-913. doi:10.1016/j.ejmech.2006.03.016
101. Bieringer, Sabine; Holzer, Wolfgang. 4-Acyl-5-hydroxy-1-phenyl-3-trifluoromethylpyrazoles: Synthesis and NMR Spectral Investigations. Heterocycles (2006), 68(9), 1825-1836. doi:10.3987/COM-05-10502
102. Eller, Gernot A.; Wimmer, Veronika; Haring, Andreas W.; Holzer, Wolfgang. An Efficient Approach to Heterocyclic Analogues of Xanthone: A Short Synthesis of all possible Pyrido[5,6]pyrano[2,3-c]pyrazol-4(1H)-ones. Synthesis (2006), (24), 4219-4229. doi:10.1055/s-2006-950324
103. Eller, Gernot A.; Holzer, Wolfgang. Synthesis and Detailed Spectroscopic Characterization of Two Novel N-(3-Acetyl-2-thienyl)acetamides. Molbank (2006), M520/1-3. doi:10.3390/M520
104. Eller, Gernot A.; Haring, Andreas W.; Datterl, Barbara; Zwettler, Maryam; Holzer, Wolfgang. Tri- and Tetracyclic Heteroaromatic Systems: Synthesis of Novel Benzo-, Benzothieno- and Thieno-Fused Pyrano[2,3-c]pyrazol-4(1H)-ones. Heterocycles (2007), 71(1), 87-104. doi:10.3987/COM-06-10908
105. Eller, Gernot A.; Holzer, Wolfgang. A Convenient Approach to Heterocyclic Building Blocks: Synthesis of Novel Ring Systems Containing a [5,6]Pyrano[2,3-c]pyrazol-4(1H)-one Moiety. Molecules (2007), 12(1), 60-73. doi:10.3390/12010060
106. Eller, Gernot A.; Datterl, Barbara; Holzer, Wolfgang. Pyrazolo[4',3':5,6]pyrano[2,3-b]quinoxalin-4(1H)-one: Synthesis and Characterization of a Novel Tetracyclic Ring System. Journal of Heterocyclic Chemistry (2007), 44(5), 1139-1143. doi:10.1002/jhet.5570440526
107. Nedzelskyte, Egle; Martynaitis,Vytas; Sackus, Algirdas; Eller, Gernot A.; Holzer, Wolfgang. Synthesis of Mono- and Dibrominated Derivatives of 1-Phenylpyrazol-3-ol. Molbank (2007), M551, 1-5. doi:10.3390/M551
108. Eller, G. A.; Wimmer, V.; Holzer, W. Synthesis of Novel Polycyclic Ring Systems Containing Two Pyrano[2,3-c]pyrazol-4(1H)-one Moieties. Khimiya Geterotsiklicheskikh Soedinenii (2007), (8), 1251-1255; Chemistry of Heterocyclic Compounds (2007), 43(8), 1060-1064. doi:10.1007/s10593-007-0165-z
109. Shanab, Karem; Pongprom, Nipawan; Wulz, Eva; Holzer, Wolfgang; Spreitzer, Helmut; Schmidt, Peter; Aicher, Babette; Mueller, Gilbert; Guenther, Eckhard. Synthesis and biological evaluation of novel cytotoxic azanaphthoquinone annelated pyrrolo oximes. Bioorganic & Medicinal Chemistry Letters (2007), 17(22), 6091-6095. doi:10.1016/j.bmcl.2007.09.054
110. Holzer, Wolfgang; Eller, Gernot A.; Schonberger, Simeon. On the Tautomerism of Cinnolin-4-ol, Cinnoline-4-thiol, and Cinnolin-4-amine. Heterocycles (2008), 75(1), 77-86. doi:10.3987/COM-07-11177
111. Shanab, Karem; Wadsak, Wolfang; Mien, Leonhard-Key; Mitterhauser, Markus; Holzer, Wolfgang; Polster, Victoria; Viernstein, Helmut; Spreitzer, Helmut. Synthesis of in Vivo Metabolites of the New Adenosine A3 Receptor Pet-Radiotracer [18F]FE@SUPPY. Heterocycles (2008), 75(2), 339-356. doi:10.3987/COM-07-11219
112. Holzer, Wolfgang; Eller, Gernot A.; Schonberger, Simeon. On the Synthesis and Reactivity of 4-(Oxiran-2-ylmethoxy)cinnoline: Targeting a Cinnoline Analogue of Propranolol. Scientia Pharmaceutica (2008), 76(1), 19-32. doi:10.3797/scipharm.0802-06
113. Eller, G. A.; Habicht, D.; Holzer, W. Synthesis of a Novel Pentacycle: 8-Methyl-10-phenylpyrazolo[4’,3’:5,6]pyrano[3,2-c][1,10]phenanthrolin-7(10H)-one Khimiya Geterotsiklicheskikh Soedinenii. (2008), (6), 884-890.; Chemistry of Heterocyclic Compounds 2008, 44(6), 709-714. doi:10.1007/s10593-008-0106-5
114. Wolf, Barbara M. T.; Eller, Gernot A.; Holzer, Wolfgang. 2-Pyrazolin-5-ones Bearing a Basic Dialkylaminoalkyl Substituent at the N1-Position: Preparation and NMR Spectroscopic Investigation. Heterocycles (2008), 75(8), 2035-2042. doi:10.3987/COM-08-11371
115. Singh, Palwinder; Mittal, Anu; Kaur, Satwinderjeet; Holzer, Wolfgang; Kumar, Subodh. 2,3-Diaryl-5-ethylsulfanylmethyltetrahydrofurans as a new class of COX-2 inhibitors and cytotoxic agents. Organic & Biomolecular Chemistry (2008), 6, 2706-2712. doi:10.1039/b803608j
116. Eller, Gernot A.; Holzer, Wolfgang. Synthesis of 4,4'-(Cyclohexane-1,1-diyl)bis(1-methyl-1H-pyrazol-5-ol). Molbank (2008), M569. doi:10.3390/M569
117. Holzer, Wolfgang; Claramunt, Rosa M.; López, Concepción; Alkorta, Ibon; Elguero, José. A study in desmotropy. Solid State Nuclear Magnetic Resonance (2008), 34(1-2), 68-76. doi:10.1016/j.ssnmr.2007.12.002
118. Pongrom, Nipawan; Muller, Gerhard; Schmidt, Peter; Holzer, Wolfgang; Spreitzer, Helmut. Synthesis of anticancer compounds, III. Bioorg Med Chem Lett (2007), 17, 6091, 2007), carbinol derivatives of azanaphthoquinone annelated pyrroles; Monatshefte fuer Chemie (2009), 140(3), 309-313. doi:10.1007/s00706-008-0024-3
119. Solovjova, Joana; Martynaitis, Vytas; Holzer, Wolfgang; Mangelinckx, Sven; De Kimpe, Norbert; Šačkus, Algirdas. Synthesis and reactions of 1-amino-1,5,6,10b-tetrahydroimidazo-[2,1-a]isoquinolin-2(3H)-ones. ARKIVOC (2009), (6), 48-62. doi:10.3998/ark.5550190.0010.606
120. Eller, Gernot A.; Zhang, Qian; Habicht, Daniela; Datterl, Barbara; Holzer, Wolfgang. Synthesis and NMR Spectroscopic Data of Pyrazolo[4',3':5,6]pyrano[2,3-b]pyrazin-4(1H)-ones: Derivatives of a Novel Tricyclic Ring System. Acta Chimica Slovenica (2009), 56(3), 521-526.
121. Holzer, Wolfgang; Eller, Gernot A.; Datterl, Barbara; Habicht, Daniela. Derivatives of Pyrazinecarboxylic Acid: 1H, 13C and 15N NMR Spectroscopic Investigations. Magnetic Resonance In Chemistry (2009), 47(7), 617-624. doi:10.1002/mrc.2437
122. Holzer, Wolfgang; Guo, Changbin; Schalle, Karin. 3-Methyl-1-phenyl-1H-pyrazol-5-yl 2-Bromo-3-furan-carboxylate. Molbank (2009), M603. doi:10.3390/M603
123. Arbačiauskienė, Eglė; Vilkauskaitė, Gytė; Eller, Gernot A.; Holzer, Wolfgang; Šačkus, Algirdas. Pd-catalyzed Cross-coupling Reactions of Halogenated 1-Phenylpyrazol-3-ols and Related Triflates. Tetrahedron (2009), 65(37), 7817-7824. doi:10.1016/j.tet.2009.07.017
124. Guo, Changbin; Holzer, Wolfgang. 4,4’-[(2-Chlorophenyl)methylene]bis[1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-ol]. Molbank (2009), M605. doi:10.3390/M605
125. Vilkauskaitė, Gytė; Eller, Gernot A.; Šačkus, Algirdas; Holzer, Wolfgang. 5-Chloro-4-iodo-1,3-dimethyl-1H-pyrazole. Molbank (2009), M620. doi:10.3390/M620
126. Fuchs, Ferdinand C.; Eller, Gernot A.; Holzer, Wolfgang. Heterocyclic Analogs of Thioflavones: Synthesis and NMR Spectroscopic Investigations. Molecules (2009), 14(9), 3814-3832. doi:10.3390/molecules14093814
127. Kleizienė, Neringa; Arbačiauskienė, Eglė; Holzer, Wolfgang; Šačkus, Algirdas. 4-Bromo-3-methoxy-1-phenyl-1H-pyrazole. Molbank (2009), M639. doi:10.3390/M639
128. Kleizienė, Neringa; Arbačiauskienė, Eglė; Holzer, Wolfgang; Šačkus, Algirdas. (2E)-3-(3-Methoxy-1-phenyl-1H-pyrazol-4-yl)-2-propenal. Molbank (2009), M644. doi:10.3390/M644
129. Solovjova, Joana; Martynaitis, Vytas; Mangelinckx, Sven; Holzer, Wolfgang; De Kimpe, Norbert; Sackus, Algirdas. Synthesis and ring opening of alkaloid-type compounds with a novel indolo[2,3-c][2]benzazepine skeleton. Synlett (2009), (19), 3119-3122. doi:10.1055/s-0029-1218340
2010–2019
130. Arbačiauskienė, E.; Kazlauskas, K.; Miasojedovas, A.; Juršėnas, S.; Jankauskas, V.; Holzer, W.; Getautis, V.; Šačkus, A. Pyrazolyl-substituted polyconjugated molecules for optoelectronic applications. Dyes and Pigments (2010), 85(3), 79-85. doi:10.1016/j.dyepig.2009.10.007
131. Arbačiauskienė, E.; Kazlauskas, K.; Miasojedovas, A.; Juršėnas, S.; Jankauskas, V.; Holzer, W.; Getautis, V.; Šačkus, A. Multifunctional polyconjugated molecules with carbazolyl and pyrazolyl moieties for optoelectronic applications. Synthetic Metals (2010), 160(5-6), 490-498. doi:10.1016/j.synthmet.2009.11.038
132. Batezila, Giselle; Holzer, W. (2-Chlorophenyl)-3-methylchromeno[2,3-c]pyrazol-4(1H)-one. Molbank (2010), M661. doi:10.3390/M661
133. Huemer, Valerie; Holzer, W. 1-Phenylpyrazolo[4',3':5,6]pyrano[3,2-c]pyridine-4(1H)-thione. Molbank (2010), M678. doi:10.3390/M678
134. Huemer, Valerie; Eller, Gernot A.; Holzer, Wolfgang. Heterocyclic analogs of xanthiones: 5,6-fused 3-methyl-1-phenylpyrano[2,3-c]pyrazol-4(1H) thiones – synthesis and NMR (1H, 13C, 15N) data. Magnetic Resonance In Chemistry (2010), 48(6), 476-782. doi:10.1002/mrc.2609
135. Shanab, Karem; Schirmer, Eva; Knafl, Heike; Wulz, Eva; Holzer, Wolfgang; Spreitzer, Helmut; Schmidt, Peter; Aicher, Babette; Müller, Gilbert; Günther, Eckhard. Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives. Bioorganic & Medicinal Chemistry Letters (2010), 20(13), 3950-3952. doi:10.1016/j.bmcl.2010.05.003
136. Holzer, Wolfgang; Ebner, Angelika; Schalle, Karin; Batezila, Gyselle; Eller, Gernot A. Novel fluoro-substituted benzo- and benzothieno fused pyrano[2,3-c]pyrazol-4(1H)-ones. Journal of Fluorine Chemistry (2010), 113(10), 1013-1024. doi:10.1016/j.jfluchem.2010.07.007
137. Singh, Palwinder; Kaur, Jatinder; Holzer, Wolfgang. Acridone based Cu2+-F-/F--Cu2+ responsive ON/OFF key pad. Sensors and Actuators B: Chemical (2010); 150(1), 50-56. doi:10.1016/j.snb.2010.07.043
138. Datterl, Barbara; Tröstner, Nicole; Kucharski, Dorota; Holzer, Wolfgang. Heterocyclic Analogues of Xanthone and Xanthione. 1H-Pyrano[2,3-c:6,5-c]dipyrazol-4(7H)-ones and Thiones: Synthesis and NMR Data. Molecules (2010), 15(9), 6106-6126. doi:10.3390/molecules15096106
139. Singh, Palwinder; Kaur, Matinder; Holzer, Wolfgang. Synthesis and evaluation of indole, pyrazole, chromone and pyrimidine based conjugates for tumor growth inhibitory activities – Development of highly efficacious cytotoxic agents. European Journal of Medicinal Chemistry (2010), 45(11), 4968-4982. doi:10.1016/j.ejmech.2010.08.004
140. Ebner, Angelika; Holzer, W. 5-(Dimethylamino)-1-(phenyl)chromeno[2,3-c]pyrazol-4(1H)-one. Molbank (2010), M706. doi:10.3390/M706
141. Eller, Gernot A.; Vilkauskaitė, Gytė; Arbačiauskienė, Eglė; Šačkus, Algirdas; Holzer, Wolfgang. The Sonogashira Coupling Offers a New Synthetic Route to Thieno[2,3-c]pyrazoles. Synthetic Communications (2011), 41/4), 541-547. doi:10.1080/00397911003629382
142. Arbačiauskienė, Eglė; Vilkauskaitė, Gytė; Šačkus, Algirdas; Holzer, Wolfgang. Ethyl 3- and 5-Triflyloxy-1H-pyrazole-4-carboxylates in the Synthesis of Condensed Pyrazoles by Pd-Catalysed Cross-Coupling Reactions. European Journal of Organic Chemistry (2011), (10), 1880-1890. doi:10.1002/ejoc.201001560
143. Shanab, Karem; Schirmer, Eva; Wulz, Eva; Weissenbacher, Barbara; Lassnig, Sigrid; Slanz, Rita; Fösleitner, Germana; Holzer, Wolfgang; Spreitzer, Helmut; Schmidt, Peter; Aicher, Babette; Müller, Gilbert; Günther, Eckhard. Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives: Part II. Bioorganic & Medicinal Chemistry Letters (2011), 21 (10), 3117-3121. doi:10.1016/j.bmcl.2011.03.013
144. Martynaitis, Vytas; Steponaviciute, Rasa; Krikstolaityte, Sonata; Solovjova, Joana; Mangelinckx, Sven; De Kimpe, Norbert; Holzer, Wolfgang; Sackus, Algirdas. Synthesis and reactions of 1-hydroxy-9,9a-dihydro-1H-imidazo[1,2-a]indol-2-(3H)-ones. Tetrahedron (2011), 67(21), 3945-3953. doi:10.1016/10.1016/j.tet.2011.03.044
145. Pfaffenhuemer, Peter; Laggner, Christian; Deibl, Stefan; Datterl, Barbara; Holzer, Wolfgang. Reactions and Tautomeric Behavior of 1-(2-Pyridinyl)-1H-pyrazol-5-ols. Heterocycles (2011), 83(7), 1567-1585. doi:10.3987/COM-11-12206
146. Pace, Vittorio; Alcántara, Andrés R.; Holzer, Wolfgang. Highly efficient chemoselective N-TBS protection of anilines under exceptional mild conditions in the eco-friendly solvent 2-methyltetrahydrofuran. Green Chemistry (2011), 13, 1986-1989. doi:10.1039/C1GC15574A
147. Pace, Vittorio; Hoyos, Pilar; Sinisterra, José Vicente; Alcántara, Andrés R.; Holzer, Wolfgang. Highly Regioselective and Efficient Synthesis of Aminoepoxides by Ring Closure of Aminohalohydrins Mediated by KF-Celite. Synlett (2011), (13), 1831-1834. doi:10.1055/s-0030-1260961
148. Vilkauskaite, Gyte; Sackus, Algirdas; Holzer, Wolfgang. Sonogashira-Type Reactions with 5-Chloro-1-phenyl-1H-pyrazole-4-carbaldehydes: A Straightforward Approach to Pyrazolo[4,3-c]pyridines. European Journal of Organic Chemistry (2011), 2011(26), 5123-5133. doi:10.1002/ejoc.201100626
149. Arbaciauskiene, Egle; Martynaitis, Vytas; Krikstolaityte, Sonata; Holzer, Wolfgang; Sackusa, Algirdas. Synthesis of 3-substituted 1-phenyl-1H-pyrazole-4-carbaldehydes and the corresponding ethanones by Pd-catalysed cross-coupling reactions. ARKIVOC (2011), (11), 1-21. doi:10.3998/ark.5550190.0012.b01
150. Pace, Vittorio; Castoldi, Laura; Holzer, Wolfgang. Highly chemoselective synthesis of aryl allylic sulfoxides through calcium hypobromite oxidation of aryl allylic sulfides. Tetrahedron Letters (2012), 53(8), 967-972. doi:10.1016/j.tetlet.2011.12.046
151. Bieliauskas, Aurimas; Martynaitis, Vytas; Getautis, Vytautas; Malinauskas, Tadas; Jankauskas, Vygintas; Kamarauskas, Egidijus; Holzer, Wolfgang; Šačkus, Algirdas. Synthesis of electroactive hydrazones derived from 3-(10-alkyl-10H-phenothiazin-3-yl)-2-propenals and their corresponding 3,3′-bispropenals. Tetrahedron (2012), 68(18), 3552-3559. doi:10.1016/j.tet.2012.03.010
152. Pace, Vittorio; Castoldi, Laura; Alcantara, Andres R.; Holzer, Wolfgang. Robust eco-friendly protocol for the preparation of γ-hydroxy-α,β-acetylenic esters by sequential one-pot elimination-addition of 2-bromoacrylates to aldehydes promoted by LTMP in 2-MeTHF. Green Chemistry (2012), 14(7), 1859-1863. doi:10.1016/10.1039/c2gc35305a
153. Pace, Vittorio; Holzer, Wolfgang. A straightforward and general access to α-phthalimido-α'-substituted propan-2-ones. Tetrahedron Letters (2012), 53(38), 5106-5109. doi:10.1016/j.tetlet.2012.07.045
154. Vilkauskaitė, Gytė; Holzer, Wolfgang; Šačkus, Algirdas. 4-{[(1-Phenyl-1H-pyrazol-3-yl)oxy]methyl}-1,3-dioxolan-2-one. Molbank (2012), M786/1-4. doi:10.3390/M786
155. Holzer, Wolfgang; Vilkauskaitė, Gytė; Arbačiauskienė, Eglė; Šačkus, Algirdas. Dipyrazolo[1,5-a:4',3'-c]pyridines – a new heterocyclic system accessed via multicomponent reaction. Beilstein Journal of Organic Chemistry (2012), 8, 2223-2229. doi:10.3762/bjoc.8.251
156. Pace, Vittorio; Vilkauskaitė, Gytė; Šačkus, Algirdas; Holzer, Wolfgang. Highly efficient and chemoselective α-iodination of acrylate esters through Morita-Baylis-Hillman-type chemistry. Organic and Biomolecular Chemistry (2013), 11(7), 1085-1088. doi:10.1039/C2OB27341A
157. Heiter, Helmut Julian; Vilkauskaite, Gyte; Holzer, Wolfgang. Pd-Assisted Cross-Coupling Reactions with 4-Chlorocinnoline. Journal of Heterocyclic Chemistry (2013), 50(1), 141-144. doi:10.1002/jhet.1050
158. Shahabi, Manochehr; Schirmer, Eva; Shanab, Karem; Leepasert, Theerachart; Ruzicka, Jana; Holzer; Wolfgang; Spreitzer, Helmut; Aicher, Babette; Schmidt, Peter; Blumenstein, Lars; Müller, Gilbert; Günther, Eckhard. Synthesis and biological evaluation of new cytotoxic indazolo[4,3-gh]isoquinolinone derivatives. Bioorganic and Medicinal Chemistry Letters (2013), 23(6), 1846-1852. doi:10.1016/j.bmcl.2013.01.022
159. Pace, Vittorio; Holzer, Wolfgang; Verniest, Guido; Alcántara, Andrés R.; De Kimpe, Norbert. Chemoselective Synthesis of N-Substituted α-Amino-α′-chloro Ketones via Chloromethylation of Glycine-Derived Weinreb Amides. Advanced Synthesis & Catalysis (2013), 355(5), 919-926. doi:10.1002/adsc.201201043
160. Pace, Vittorio; Hoyos, Pilar; Alcantara, Andres R.; Holzer, Wolfgang. Chemoselective CaO-Mediated Acylation of Alcohols and Amines in 2-Methyltetrahydrofuran. ChemSusChem (2013), 6(5), 905-910. doi:10.1002/cssc.201200922
161. Pace, Vittorio; Holzer, Wolfgang. Chemoselective Activation Strategies of Amidic Carbonyls towards Nucleophilic Reagents. Australian Journal of Chemistry (2013), 66(5), 507-510. doi:10.1071/CH13042
162. Pace, Vittorio; Castoldi, Laura; Alcantara, Andres R.; Holzer, Wolfgang. Highly efficient and environmentally benign preparation of Weinreb amides in the biphasic system 2-MeTHF/water. RSC Advances (2013), 3(26), 10158-10162. doi:10.1039/C3RA41262H
163. Pace, Vittorio; Castoldi, Laura; Holzer, Wolfgang. Synthesis of alpha,beta-Unsaturated-alpha'-Haloketones through the Chemoselective Addition of Halomethyllithiums to Weinreb Amides. Journal of Organic Chemistry (2013), 78(15), 7764-7770. doi:10.1021/jo401236t
164. Pace, Vittorio; Castoldi, Laura; Hernáiz, María J.; Alcántara, Andrés R.; Holzer, Wolfgang. Chemoselective oxidative hydrolysis of EWG protected α-arylamino vinyl bromides to α-arylamino-α′-bromoacetones. Tetrahedron Letters (2013), 54(33), 4369-4372. doi:10.1016/j.tetlet.2013.05.118
165. Pace, Vittorio; Castoldi, Laura; Holzer, Wolfgang. Addition of lithium carbenoids to isocyanates: a direct access to synthetically useful N-substituted 2-haloacetamides. Chemical Communications (Cambridge, United Kingdom) (2013), 49(75), 8383-8385. doi:10.1039/c3cc44255a
166. Leepasert, Theerachart; Shahabi, Manochehr; Shanab, Karem; Schirmer, Eva; Holzer, Wolfgang; Spreitzer, Helmut; Aicher, Babette; Müller, Gilbert; Günther, Eckhard. Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives. Bioorganic & Medicinal Chemistry Letters (2013), 23(19), 5264-5266. doi:10.1016/j.bmcl.2013.08.021
167. Paliulis, Osvaldas; Peters, Dan; Holzer, Wolfgang; Šačkus, Algirdas. Synthesis of 10-methyl-8,10-diazabicyclo[4.3.1]decane as a new building block for nicotinic modulators. ARKIVOC (2013), (4), 240-250. doi:10.3998/ark.5550190.p008.202
168. Dagilienė, Miglė ; Martynaitis, Vytas; Vengris, Mikas; Redeckas, Kipras; Voiciuk, Vladislava; Holzer, Wolfgang; Šačkus, Algirdas. Synthesis of 1’,3,3’,4-tetrahydrospiro[chromene-2,2’-indoles] as a new class of ultrafast light-driven molecular Switch. Tetrahedron (2013), 69(44), 9309-9315. doi:10.1016/j.tet.2013.08.020
169. Mulla, Dafina; Kracher, Daniel; Ludwig, Roland; Nagy, Gabor; Grandits, Melanie; Holzer, Wolfgang; Saber, Yasser; Gabra, Nermeen; Viernstein, Helmut; Unger, Frank M. Azido derivatives of cellobiose: oxidation at C1 with cellobiose dehydrogenase from Sclerotium rolfsii. Carbohydrate Research (2013), 382, 86-94. doi:10.1016/j.carres.2013.09.004
170. Vilkauskaitė, Gytė; Schaaf, Patricia; Šačkus, Algirdas; Krystof, Vladimir; Holzer, Wolfgang. Synthesis of pyridyl substituted pyrazolo[4,3-c]pyridines as potential inhibitors of protein kinases. ARKIVOC (2014), (2), 135-149. doi:10.3998/ark.5550190.p008.188
171. Singh, Palwinder; Singh, Amrinder; Kaur, Jagroop; Holzer, Wolfgang. H-Bond activated glycosylation of nucleobases: implications for prebiotic nucleoside synthesis. RSC Advances (2014), 4(7), 3158-3161. doi:10.1039/c3ra44776f
172. Pace, Vittorio; Castoldi, Laura; Holzer, Wolfgang. Chemoselective Additions of Chloromethyllithium Carbenoid to Cyclic Enones: A Direct Access to Chloromethyl Allylic Alcohols. Advanced Synthesis & Catalysis (2014), 356(8), 1761-1766. doi:10.1002/adsc.201301042
173. Tarabová, Denisa; Šoralová, Stanislava; Breza, Martin; Fronc, Marek; Holzer, Wolfgang; Milata, Viktor. Use of activated enol ethers in the synthesis of pyrazoles: reactions with hydrazine and a study of pyrazole tautomerism. Beilstein Journal of Organic Chemistry (2014), 10, 752-760. doi:10.3762/bjoc.10.70
174. Shanab, Karem; Neudorfer, Catharina; Holzer, Wolfgang ; Mitterhauser, Markus; Wadsak, Wolfgang; Spreitzer, Helmut. A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer. Molecules (2014), 19(4), 4076-4082. doi:10.3390/molecules19044076
175. Neudorfer, Catharina; Shanab, Karem ; Jurik, Andreas; Schreiber, Veronika; Neudorfer, Carolina; Vraka, Chrysoula; Schirmer, Eva; Holzer, Wolfgang; Ecker, Gerhard; Mitterhauser, Markus; Wadsak, Wolfgang; Spreitzer, Helmut. Development of potential selective and reversible pyrazoline based MAO-B inhibitors as MAO-B PET tracer precursors and reference substances for the early detection of Alzheimer’s disease. Bioorganic & Medicinal Chemistry (2014), 24(18), 4490-4495. doi:10.1016/j.bmcl.2014.07.085
176. Palka, Barbara; Holzer, Wolfgang; Di Capua, Angela; Anzini, Maurizio; Vilkauskaite, Gyte; Sackus, Algirdas. Synthesis of trifluoromethyl-substituted pyrazolo[4,3-c]pyridines - sequential versus multicomponent reaction Approach. Beilstein Journal of Organic Chemistry (2014), 10, 1759-64. doi:10.3762/bjoc.10.183
177. Pace, Vittorio; Castoldi, Laura; Mamuye, Ashenafi Damtew; Holzer, Wolfgang. Homologation of isocyanates with lithium carbenoids: A straightforward access to α-halomethyl- and α,α-dihalomethylamides. Synthesis (2014), 46(21), 2897-2909. doi:10.1055/s-0034-1379209
178. Pace, Vittorio; Holzer, Wolfgang; Olofsson, Berit. Increasing the Reactivity of Amides towards Organometallic Reagents: An Overview. Advanced Synthesis & Catalysis (2014), 356(18), 3697-3736. doi:10.1002/adsc.201400630
179. Alcantara, Andres R; Pace, Vittorio; Hoyos, Pilar; Sandoval, Manuel; Holzer, Wolfgang; Hernaiz, Maria J. Chemoenzymatic synthesis of carbohydrates as antidiabetic and anticancer drugs. Current Topics In Medicinal Chemistry (2014), 14(23), 2694-711. doi:10.2174/1568026614666141215151056
180. Pace, Vittorio; Holzer, Wolfgang; Hoyos, Pilar; Hernáiz, María José; Alcántara, Andrés R. 2-Methyltetrahydrofuran. e-EROS Encyclopedia of Reagents for Organic Synthesis. (2014), 1–6. doi:10.1002/047084289X.rn01637
181. Neudorfer, Catharina; Seddik, Amir; Shanab, Karem; Jurik, Andreas; Rami-Mark, Christina; Holzer, Wolfgang; Ecker, Gerhard; Mitterhauser, Markus; Wadsak, Wolfgang; Spreitzer, Helmut. Synthesis and in silico evaluation of novel compounds for PET-based investigations of the norepinephrine Transporter. Molecules (2015), 20(1), 1712-1730. doi:10.3390/molecules20011712
182. Mamuye, Ashenafi Damtew; Castoldi, Laura; Azzena, Ugo; Holzer, Wolfgang; Pace, Vittorio. Chemoselective efficient synthesis of functionalized β-oxonitriles through cyanomethylation of Weinreb amides. Organic & Biomolecular Chemistry (2015), 13(7), 1969-1973. doi:10.1039/C4OB02398F
183. Milisiunaite, Vaida; Arbaciauskiene, Egle; Bieliauskas, Aurimas; Vilkauskaite, Gyte; Sackus, Algirdas; Holzer, Wolfgang. Synthesis of pyrazolo[4',3':3,4]pyrido[1,2-a]benzimidazoles and related new ring systems by tandem cyclisation of vic-alkynylpyrazole-4-carbaldehydes with (het)aryl-1,2-diamines and investigation of their optical properties. Tetrahedron (2015), 71(21), 3385-3395. doi:10.1016/j.tet.2015.03.092
184. Neudorfer, Catharina; Shanab, Karem; Holzer, Wolfgang; Rami-Mark, Christina; Mitterhauser, Markus; Wadsak, Wolfgang; Spreitzer, Helmut. 2-Fluoro-N-methyl-N-({(3S,4S)-4-[2-(trifluoromethyl)phenoxy]-3,4-dihydro-1H-isochromen-3-yl}methyl)ethanamine. Molbank (2015), M858. doi:10.3390/M858
185. Mamuye, Ashenafi Damtew; Monticelli, Serena; Castoldi, Laura; Holzer, Wolfgang; Pace, Vittorio. Eco-friendly Chemoselective N-Functionalization of Isatines mediated by Supported KF in 2-MeTHF. Green Chemistry (2015), 17(8), 4194-4197. doi:10.1039/C5GC01002K
186. Arbaciauskiene, Egle; Laukaityte, Vaida; Holzer, Wolfgang; Sackus, Algirdas. Metal-Free Intramolecular Alkyne-Azide Cycloaddition To Construct the Pyraz-olo[4,3-f][1,2,3]triazolo[5,1-c][1,4]oxazepine Ring System. European Journal of Organic Chemistry (2015), 2015(25), 5663-5670. 10.1002/ejoc.201500541
187. Neudorfer, Catharina; Shanab, Karem; Holzer, Wolfgang; Rami-Mark, Christina; Mitterhauser, Markus; Wadsak, Wolfgang; Spreitzer, Helmut. 2-fluoro-N-methyl-N-{[(3s*,4s*)-4-(2-methylphenoxy)-3,4-dihydro-1H-isochromen-3-yl]methyl}ethanamine. Molbank (2015), M862. doi:10.3390/M858
188. Pace, Vittorio; Castoldi, Laura; Monticelli, Serena; Safranek, Sandra; Roller, Alexander; Langer, Thierry; Holzer, Wolfgang. A Robust, Eco-Friendly Access to Secondary Thioamides through the Addition of Organolithium Reagents to Isothiocyanates in Cyclopentyl Methyl Ether (CPME). Chemistry - A European Journal (2015), 21(52), 18966-18970. doi:10.1002/chem.201504247
189. Neudorfer, Catharina; Eberherr, Nadine; Shanab, Karem; Holzer, Wolfgang; Rami-Mark, Christina; Mitterhauser, Markus; Wadsak, Wolfgang; Spreitzer, Helmut. 1-(3-Amino-1-phenylpropyl)-3-(2-fluorophenyl)-1,3-dihydro-2H-benzimidazol-2-one. Molbank (2015), M867. doi:10.3390/M858
190. Pace, Vittorio; Pelosi, Azzurra; Antermite, Daniele; Rosati, Ornelio; Curini, Massimo; Holzer, Wolfgang. Bromomethyllithium-mediated chemoselective homologation of disulfides to dithioacetals. Chemical Communications (Cambridge, United Kingdom) (2016), 52(12), 2639-2642. doi:10.1039/C5CC10280D
191. Pace, Vittorio; Castoldi, Laura; Mamuye, Ashenafi Damtew; Langer, Thierry; Holzer, Wolfgang. Chemoselective Addition of Halomethyllithiums to Functionalized Isatins: A Straightforward Access to Spiro-Epoxyoxindoles. Advanced Synthesis & Catalysis (2016), 358(2), 172-177. doi:10.1002/adsc.201500840
192. Mueller, Monika; Weinmann, Daniela; Toegel, Stefan; Holzer, Wolfgang; Unger, Frank M.; Viernstein, Helmut. Compounds from Caesalpinia sappan with anti-inflammatory properties in macrophages and chondrocytes. Food & Function (2016), 7(3), 1671-1679. doi:10.1039/c5fo01256b
193. Pace, Vittorio; Murgia, Irene; Westermayer, Sophie; Langer, Thierry; Holzer, Wolfgang. Highly efficient synthesis of functionalized α-oxyketones via Weinreb amides homologation with α-oxygenated organolithiums. Chemical Communications (Cambridge, United Kingdom) (2016), (2016), 52(48), 7584-7587. doi:10.1039/C6CC03532A
194. Pace, Vittorio; Holzer, Wolfgang; De Kimpe, Norbert. Lithium Halomethylcarbenoids: Preparation and Use in the Homologation of Carbon Electrophiles. Chemical Record (2016), 16(4), 2061-2076. doi:10.1002/tcr.201600011
195. Pace, Vittorio; Holzer, Wolfgang; Meng, Guangrong; Shi, Shicheng; Lalancette, Roger; Szostak, Roman; Szostak, Michal. Structures of Highly Twisted Amides Relevant to Amide N-C Cross-Coupling: Evidence for Ground-State Amide Destabilization. Chemistry - A European European Journal (2016), 22(41), 14494-14498. doi:10.1002/chem.201603543
Corrigendum: Chemistry - A European European Journal (2017), 23(14), 3496. doi:10.1002/chem.201700561
196. Schuster, Roswitha; Holzer, Wolfgang; Doerfler, Hannes; Weckwerth, Wolfram; Viernstein, Helmut; Okonogi, Siriporn; Mueller, Monika. Cajanus cajan - a source of PPARγ activators leading to anti-inflammatory and cytotoxic effects. Food & Function (2016), 7(9), 3798-3806. doi:10.1039/C6FO00689B
197. Okonogi, Siriporn; Kheawfu, Kantaporn; Holzer, Wolfgang; Unger, Frank M.; Viernstein, Helmut; Mueller, Monika. Anti-inflammatory Effects of Compounds from Polygonum odoratum. Natural Product Communications (2016), 11(11), 1651-1654.
198. Monticelli, Serena; Parisi, Giovanna; Rui, Marta; de la Vega-Hernandez, Karen; Murgia, Irene; Senatore, Raffaele; Holzer, Wolfgang; Urban, Ernst; Langer, Thierry; Pace, Vittorio. The Use of the Comins-Meyers Amide in Synthetic Chemistry: an Overview. Natural Product Communications (2016), 11(11), 1729-1732.
199. Praznik, Werner; Cavarkapa, Andrea; Unger, Frank M.; Loeppert, Renate; Holzer, Wolfgang; Viernstein, Helmut; Mueller, Monika. Molecular dimensions and structural features of neutral polysaccharides from the seed mucilage of Hyptis suaveolens L. Food Chemistry (2017), 221, 1997-2004. doi:10.1016/j.foodchem.2016.11.087
200. Schuster, Roswitha; Zeindl, Laura; Holzer, Wolfgang; Khumpirapang, Nattakanwadee; Okonogi, Siriporn; Viernstein, Helmut; Mueller, Monika, Eulophia macrobulbon – an orchid with significant anti-inflammatory and antioxidant effect and anticancerogenic potential exerted by its root extract. Phytomedicine (2017), 24, 157-165. doi:10.1016/j.phymed.2016.11.018
201. Parisi, Giovanna; Degennaro, Leonardo; Carlucci, Claudia; de Candia, Modesto; Mastrorilli, Pietro; Roller, Alexander; Holzer, Wolfgang; Altomare, Cosimo Damiano; Pace, Vittorio; Luisi, Renzo. A Greener and Efficient Access to Substituted Four- and Six-membered Sulfur-bearing Heterocycles. Organic & Biomolecular Chemistry (2017), 15(23), 5000-5015. doi:10.1039/c7ob00846e
202. Jansa, Josef; Schmidt, Ramona; Mamuye, Ashenafi Damtew; Castoldi, Laura; Roller, Alexander; Pace, Vittorio; Holzer, Wolfgang. Synthesis of tetrasubstituted pyrazoles containing pyridinyl substituents. Beilstein Journal of Organic Chemistry (2017), 13, 895-902. doi:10.3762/bjoc.13.90
203. Castoldi, Laura; Holzer, Wolfgang; Langer, Thierry; Pace, Vittorio. Evidence and Isolation of Tetrahedral Intermediates Formed upon the Addition of Lithium Carbenoids to Weinreb Amides and N-acylpyrroles. Chemical Communications (Cambridge, United Kingdom) (2017), 53(68), 9498-9501. doi:10.1039/c7cc05215d
204. Pace, Vittorio; Castoldi, Laura; Mazzeo, Eugenia; Rui, Marta; Langer, Thierry; Holzer, Wolfgang. Efficient Access to All-Carbon Quaternary and Tertiary α-Functionalized Homoallyl-type Aldehydes from Ketones. Angewandte Chemie, International Edition (2017), 56(41), 12677-12682. doi:10.1002/anie.201706236; Angewandte Chemie (2017), 129(41), 12851-12856. 10.1002/ange.201706236
205. Parisi, Giovanna; Colella, Marco; Monticelli, Serena; Romanazzi, Giuseppe; Holzer, Wolfgang; Langer, Thierry; Degennaro, Leonardo; Pace, Vittorio; Luisi, Renzo. Exploiting a "Beast" in Carbenoid Chemistry: Development of a Straightforward Direct Nucleophilic Fluoromethylation Strategy. Journal of the American Chemical Society (2017), 139(39), 13648-13651. doi:10.1021/jacs.7b07891
206. Eller, Gernot A.; Holzer, Wolfgang. Synthesis and Nmr-Spectroscopic Investigations with 4-Chloroacyl-1-phenylpyrazolin-5-ones. Journal of Heterocyclic Chemistry (2018), 55(1), 132-137. doi:10.1002/jhet.3015
207. Arbačiauskienė, Eglė; Krikštolaitytė, Sonata; Mitrulevičienė, Aiva; Bieliauskas, Aurimas; Martynaitis, Vytas; Bechmann, Matthias; Roller, Alexander; Šačkus, Algirdas; Holzer, Wolfgang. On the Tautomerism of N-Substituted Pyrazolones: 1,2-Dihydro-3H-pyrazol-3-ones versus 1H-Pyrazol-3-ols. Molecules 2018, 23(1), 129. doi:10.3390/molecules23010129
208. Praznik, Werner; Okonogi, Siriporn; Unger, Frank Michael; Viernstein, Helmut; Holzer, Wolfgang; Mueller, Monika; Cavarkapa, Andrea. Prebiotic compositions comprising oligosaccharides from hyptis suaveolens. Eur. Pat. Appl. (2018), EP 3275446 A1.
209. Castoldi, Laura; Ielo, Laura; Holzer, Wolfgang; Giester, Gerald; Roller, Alexander; Pace, Vittorio. α-Arylamino Diazoketones: Diazomethane-Loading Controlled Synthesis, Spectroscopic Investigations, and Structural X-ray Analysis. Journal of Organic Chemistry (2018), 83(8), 4336-4347. doi:10.1021/acs.joc.7b03134
210. Castoldi, Laura; Ielo, Laura; Hoyos, Pilar; Hernaiz, Maria J.; De Luca, Laura; Alcantara, Andres R.; Holzer, Wolfgang; Pace, Vittorio. Merging lithium carbenoid homologation and enzymatic reduction: A combinative approach to the HIV-protease inhibitor Nelfinavir. Tetrahedron (2018), 74(18), 2211-2217. doi:10.1016/j.tet.2018.03.034
211. Arbačiauskienė, Eglė; Krikštolaitytė, Sonata; Mitrulevičienė, Aiva; Bieliauskas, Aurimas; Martynaitis, Vytas; Bechmann, Matthias; Roller, Alexander; Šačkus, Algirdas; Holzer, Wolfgang. On the Tautomerism of N-Substituted Pyrazolones: 1,2-Dihydro-3H-pyrazol-3-ones versus 1H-Pyrazol-3-ols. Molecules 2018, 23(1), 129. doi:10.3390/molecules23010129
212. Milisiunaite, Vaida; Arbaciauskiene, Egle; Reznickova, Eva; Jorda, Radek; Malinkova, Veronika; Zukauskaite, Asta; Holzer, Wolfgang; Sackus, Algirdas; Krystof, Vladimir. Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines. European Journal of Medicinal Chemistry (2018), 150, 908-919 doi:10.1016/j.ejmech.2018.03.037
213. Senatore, Raffaele; Castoldi, Laura; Ielo, Laura; Holzer, Wolfgang; Pace, Vittorio. Expeditious and Chemoselective Synthesis of α-Aryl and α-Alkyl Selenomethylketones via Homologation Chemistry. Organic Letters (2018), 20(9), 2685-2688. doi:10.1021/acs.orglett.8b00896
214. Senatore, Raffaele; Ielo, Laura; Urban, Ernst; Holzer, Wolfgang; Pace, Vittorio. Substituted α-Sulfur Methyl Carbanions: Effective Homologating Agents for the Chemoselective Preparation of β-Oxo Thioethers from Weinreb Amides. European Journal of Organic Chemistry (2018), (20-21), 2466-2470. doi:10.1002/ejoc.201800095
215. Eller, Gernot A.; Vilkauskaitė, Gytė; Šačkus, Algirdas; Martynaitis, Vytas; Mamuye, Ashenafi Damtew; Pace, Vittorio; Holzer, Wolfgang. An unusual thionyl chloride-promoted C−C bond formation to obtain 4,4'-bipyrazolones. Beilstein Journal of Organic Chemistry (2018), (14), 1287-1292. doi:10.3762/bjoc.14.110
216. Sackus, Algirdas; Zukauskaite, Zivile; Kleiziene, Neringa; Bieliauskas, Aurimas; Amankaviciene, Virgine; Holzer, Wolfgang; Martynaitis, Vytas. One-pot synthesis of polycyclic heterocyclic compounds by condensation of 1-carbamoylmethyl-2,3,3-trimethyl-3H-indolium salts with pyridine-2, 3, and 4- and quinoline-4-carboxaldehydes. Tetrahedron (2018), 74(27), 3679-3690. doi:10.1016/j.tet.2018.05.036
217. Touqeer, Saad; Castoldi, Laura; Langer, Thierry; Holzer, Wolfgang; Pace, Vittorio. Homologation of halostannanes with carbenoids: a convenient and straightforward one-step access to α-functionalized organotin reagents. Chemical Communications (Cambridge, United Kingdom) (2018), 54, 10112-10115. doi:10.1039/c8cc04786c
218. Bieliauskas, Aurimas; Krikštolaitytė, Sonata; Holzer, Wolfgang; Šačkus, Algirdas. Ring-closing metathesis as a key step to construct the 2,6-dihydropyrano[2,3-c]pyrazole ring system. ARKIVOC (2018), (5), 296-307. doi: 10.24820/ark.5550190.p010.407
219. de la Vega-Hernandez, Karen; Senatore, Raffaele; Miele, Margherita; Urban, Ernst; Holzer, Wolfgang; Pace, Vittorio. Chemoselective reduction of isothiocyanates to thioformamides mediated by the Schwartz reagent. Organic & Biomolecular Chemistry (2019), 17(7), 1970-1978. doi: 10.1039/c8ob02312c
220. Stadler, Marco; Monticelli, Serena; Seidel, Thomas; Luger, Denise; Salzer, Isabella; Boehm, Stefan; Holzer, Wolfgang; Schwarzer, Christoph; Urban, Ernst; Khom, Sophia; Langer, Thierry; Pace, Vittorio; Hering, Steffen. Design, Synthesis, and Pharmacological Evaluation of Novel β2/3 Subunit-Selective γ-Aminobutyric Acid Type A (GABAA) Receptor Modulators. Journal of Medicinal Chemistry (2019), 62(1), 317-341. doi: 10.1021/acs.jmedchem.8b00859
221. Monticelli, Serena; Colella, Marco; Pillari, Veronica; Tota, Arianna; Langer, Thierry; Holzer, Wolfgang; Degennaro, Leonardo; Luisi, Renzo; Pace, Vittorio. Modular and Chemoselective Strategy for the Direct Access to α-Fluoroepoxides and Aziridines via the Addition of Fluoroiodomethyllithium to Carbonyl-Like Compounds. Organic Letters (2019), 21(2), 584-588. doi: 10.1021/acs.orglett.8b04001
222. Monticelli, Serena; Urban, Ernst ; Langer, Thierry; Holzer, Wolfgang; Pace, Vittorio. A Straightforward Homologation of Carbon Dioxide with Magnesium Carbenoids en Route to α-Halocarboxylic Acids. Advanced Synthesis & Catalysis (2019), 361(5), 1001-1006. doi: 10.1002/adsc.201801614
223. Ielo, Laura; Touqeer, Saad; Roller, Alexander; Langer, Thierry; Holzer, Wolfgang; Pace, Vittorio. Telescoped, Divergent, Chemoselective C1 and C1-C1 Homologation of Imine Surrogates: Access to Quaternary Chloro- and Halomethyl-Trifluoromethyl Aziridines. Angewandte Chemie, International Edition (2019), 58(8), 2479-2484. doi:10.1002/anie.201812525; Angewandte Chemie (2019), 131(8), 2501-2506). 10.1002/ange.201812525
224. Unger, Frank M.; Viernstein, Helmut; Holzer, Wolfgang; Midpanon, Supatta. Method for separating chromatographically indistinguishable 2-azido-1-nitrates. PCT Int. Appl. (2019), WO 2019002594 A1.
225. Monticelli, Serena; Holzer, Wolfgang; Langer, Thierry; Roller, Alexander; Olofsson, Berit; Pace, Vittorio. Sustainable Asymmetric Organolithium Chemistry: Enantio- and Chemoselective Acylations through Recycling of Solvent, Sparteine and Weinreb "Amine". ChemSusChem (2019), 12(6), 1147-1154. doi: 10.1002/cssc.201802815
226. Pace, Vittorio; Holzer, Wolfgang; Ielo, Laura; Shi, Shicheng; Meng, Guangrong; Hanna, Mina; Szostak, Roman; Szostak, Michal. 17O NMR and 15N NMR chemical shifts of sterically-hindered amides: ground-state destabilization in amide electrophilicity. Chemical Communications (Cambridge, United Kingdom) (2019), 55(30), 4423-4426. doi: 10.1039/c9cc01402k
227. Holzer, Wolfgang; Castoldi, Laura; Kyselova, Viktoriya; Sanz, Dionisia; Claramunt, Rosa M.; Torralba, M. Carmen; Alkorta, Ibon; Elguero, Jose. Multinuclear NMR spectra and GIAO/DFT calculations of N-benzylazoles and N-benzylbenzazoles. Structural Chemistry (2019), 30(5), 1729-1735. doi: 10.1007/s11224-019-01310-3
228. Milisiunaite, Vaida; Paulaviciute, Ruta; Arbaciauskiene, Egle; Martynaitis, Vytas; Holzer, Wolfgang; Sackus, Algirdas. Synthesis of 2H-furo[2,3-c]pyrazole ring systems through silver(I) ion-mediated ring-closure reaction. Beilstein Journal of Organic Chemistry (2019), (15), 679-684. doi: 10.3762/bjoc.15.62
229. Stadler, Marco; Monticelli, Serena; Seidel, Thomas; Luger, Denise; Salzer, Isabella; Boehm, Stefan; Holzer, Wolfgang; Schwarzer, Christoph; Urban, Ernst; Khom, Sophia; Langer, Thierry; Pace, Vittorio; Hering, Steffen. Design, Synthesis, and Pharmacological Evaluation of Novel β2/3 Subunit-Selective γ-Aminobutyric Acid Type A (GABAA) Receptor Modulators. Journal of Medicinal Chemistry (2019), 62(1), 317-341. doi: 10.1021/acs.jmedchem.8b00859
230. Miele, Margherita; D'Orsi, Rosarita; Sridharan, Vellaisamy; Holzer, Wolfgang; Pace, Vittorio. Highly chemoselective difluoromethylative homologation of iso(thio)cyanates: expeditious access to unprecedented α,α-difluoro(thio)amides. Chemical Communications (Cambridge, United Kingdom) (2019), 55, 12960-12963. doi: 10.1039/c9cc06929a
231. Miele, Margherita; Citarella, Andrea; Micale, Nicola; Holzer, Wolfgang; Pace, Vittorio. Direct and Chemoselective Synthesis of Tertiary Difluoroketones via Weinreb Amide Homologation with a CHF2-Carbene Equivalent. Organic Letters (2019), 21 (20), 8261-8265. doi: 10.1021/acs.orglett.9b03024
232. Milisiunaite, Vaida; Kadlecova, Alena; Zukauskaite, Asta; Dolezal, Karel; Strnad, Miroslav; Voller, Jiri; Arbaciauskiene, Egle; Holzer, Wolfgang; Sackus, Algirdas. Synthesis and anthelmintic activity of benzopyrano[2,3-c]pyrazol-4(2H)-one derivatives. Molecular Diversity (2020), 24(4), 1025-1042. doi: 10.1007/s11030-019-10010-3
2020–
233. Senatore, Raffaele; Malik, Monika; Spreitzer, Markus; Holzer, Wolfgang; Pace, Vittorio. Direct and Chemoselective Electrophilic Monofluoromethylation of Heteroatoms (O-, S-, N-, P-, Se-) with Fluoroiodomethane. Organic Letters (2020), 22(4), 1345-1349. doi: 10.1021/acs.orglett.9b04654
234. Senatore, Raffaele; Malik, Monika; Touqeer, Saad; Listro, Roberta; Collina, Simona; Holzer, Wolfgang; Pace, Vittorio. Straightforward and direct access to β-seleno- amines and sulfonylamides via the controlled addition of phenylselenomethyllithium (LiCH2SePh) to imines. Tetrahedron (2020), 76(51), 131220. doi: 10.1016/j.tet.2020.131220
235. Ielo Laura; Holzer Wolfgang; Pace Vittorio; Rahman Md Mahbubur; Meng Guangrong; Szostak Roman; Szostak Michal. Electrophilicity Scale of Activated Amides: 17O NMR and 15N NMR Chemical Shifts of Acyclic Twisted Amides in N-C(O) Cross-Coupling. Chemistry - A European Journal (2020), 26(69), 16246-16250. doi: 10.1002/chem.202003213
236. Ozenil, Marius; Pacher, Katharina; Balber, Theresa; Vraka, Chrysoula; Roller, Alexander; Holzer, Wolfgang; Spreitzer, Helmut; Mitterhauser, Markus; Wadsak, Wolfgang; Hacker, Marcus; Pichler, Verena. Enhanced arecoline derivatives as muscarinic acetylcholine receptor M1 ligands for potential application as PET radiotracers. European Journal of Medicinal Chemistry (2020), 204, 112623. doi: 10.1016/j.ejmech.2020.112623
237. Ielo, Laura; Pillari, Veronica; Gajic, Natalie; Holzer, Wolfgang; Pace, Vittori. Straightforward chemoselective access to unsymmetrical dithioacetals through a thiosulfonate homologation-nucleophilic substitution sequence. Chemical Communications (Cambridge, United Kingdom) (2020), 56(82), 12395-12398. doi: 10.1039/d0cc04896h
238. Ielo, Laura; Castoldi, Laura; Touqeer, Saad; Lombino, Jessica; Roller, Alexander; Prandi, Cristina; Holzer, Wolfgang; Pace, Vittorio. Halogen-Imparted Reactivity in Lithium Carbenoid Mediated Homologations of Imine Surrogates: Direct Assembly of bis-Trifluoromethyl-β-Diketiminates and the Dual Role of LiCH2I. Angewandte Chemie, International Edition (2020), 59(47), 20852-20857. doi:10.1002/anie.202007954; Angewandte Chemie, (2020), 132(47), 21038-21043. 10.1002/ange.202007954
239. Miele, Margherita; Citarella, Andrea; Langer, Thierry; Urban, Ernst; Zehl, Martin; Holzer, Wolfgang; Ielo, Laura; Pace, Vittorio. Chemoselective Homologation-Deoxygenation Strategy Enabling the Direct Conversion of Carbonyls into (n+1)-Halomethyl-Alkanes. Organic Letters (2020), 22(19), 7629-7634. 10.1021/acs.orglett.0c02831
240. Ielo, Laura; Pillari, Veronica; Miele, Margherita; Holzer, Wolfgang; Pace, Vittorio. Consecutive C1-Homologation / Displacement Strategy for Converting Thiosulfonates into O,S-Oxothioacetals. Advanced Synthesis & Catalysis (2020), 362(23), 5444-5449. 10.1002/adsc.202000919
241. Ozenil, Marius; Aronow, Jonas; Piljak, Daniela; Vraka, Chrysoula; Holzer, Wolfgang; Spreitzer, Helmut; Wadsak, Wolfgang; Hacker, Marcus; Pichler, Verena. Synthesis, biological, and computational evaluation of antagonistic, chiral hydrobenzoin esters of arecaidine targeting mAChR M1. Pharmaceuticals (2020), 13(12), 437. 10.3390/ph13120437
242. Ielo, Laura; Miele, Margherita; Pillari, Veronica; Senatore, Raffaele; Mirabile, Salvatore; Gitto, Rosaria; Holzer, Wolfgang; Alcantara, Andres R.; Pace, Vittorio. Taking advantage of lithium monohalocarbenoid intrinsic α-elimination in 2-MeTHF: controlled epoxide ring-opening en route to halohydrins. Organic & Biomolecular Chemistry (2021), 19(9), 2038-2043. 10.1039/d0ob02407d
243. Citarella, Andrea; Gentile, Davide; Rescifina, Antonio; Piperno, Anna; Mognetti, Barbara; Gribaudo, Giorgio; Sciortino, Maria T.; Holzer, Wolfgang; Pace, Vittorio; Micale, Nicola. Pseudo-Dipeptide Bearing α,α-Difluoromethyl Ketone Moiety as Electrophilic Warhead with Activity against Coronaviruses International Journal of Molecular Sciences (2021), 22(3). 10.3390/ijms22031398
244. Senatore, Raffaele; Malik, Monika; Urban, Ernst; Holzer, Wolfgang; Pace, Vittorio. Synthesis of stable α-fluoromethyl putative carbanions via a chemoselective reduction-monofluoromethylation sequence of diselenides under sustainable conditions. Tetrahedron (2021), 85, 131921. 10.1016/j.tet.2021.131921
245. Touqeer, Saad; Ielo, Laura; Miele, Margherita; Urban, Ernst; Holzer, Wolfgang; Pace, Vittorio. Direct and straightforward transfer of C1 functionalized synthons to phosphorous electrophiles for accessing gem-P-containing methanes. Organic & Biomolecular Chemistry (2021), 19(11), 2425-2429.10.1039/d1ob00273b
246. Alkorta, Ibon; Claramunt, Rosa M.; Sanz, Dionisia; Elguero, Jose; Holzer, Wolfgang. A 13C chemical shifts study of iodopyrazoles: experimental results and relativistic and non-relativistic calculations. Structural Chemistry (2021), 32(3), 925-937.10.1007/s11224-021-01755-5
247. Senatore, Raffaele; Malik, Monika; Langer, Thierry; Holzer, Wolfgang; Pace, Vittorio. Consecutive and Selective Double Methylene Insertion of Lithium Carbenoids to Isothiocyanates: A Direct Assembly of Four-Membered Sulfur-Containing Cycles. Angewandte Chemie, International Edition (2021), 60(47), 24854-24858. doi:10.1002/anie.202110641; Angewandte Chemie, (2021), 133(47), 25058-25062. 10.1002/ange.202110641
248. Ozenil, Marius; Skos, Lukas; Roller, Alexander; Gajic, Natalie; Holzer, Wolfgang; Spreitzer, Helmut; Platzer-Ozenil, Sonja; Vraka, Chrysoula; Hacker, Marcus; Wadsak, Wolfgang; Pichler, Verena. Unexpected scaffold rearrangement product of pirenzepine found in commercial samples. Scientific Reports (2021), 11(1), 23397. 10.1038/s41598-021-02732-y
249. Kilian, Jonas; Millard, Marlon; Ozenil, Marius; Krause, Dominik; Ghaderi, Khadija; Holzer, Wolfgang; Urban, Ernst; Spreitzer, Helmut; Wadsak, Wolfgang; Hacker, Marcus; Langer, Thierry; Pichler, Verena. Synthesis, Biological Evaluation, and Docking Studies of Antagonistic Hydroxylated Arecaidine Esters Targeting mAChRs. Molecules (2022), 27(10), 3173. 10.3390/molecules27103173
250. Kilian, Jonas; Ozenil, Marius; Millard, Marlon; Fürtös, Dorka; Maisetschläger, Verena; Holzer, Wolfgang; Wadsak, Wolfgang; Hacker, Marcus; Langer, Thierry; Pichler, Verena. Design, Synthesis, and Biological Evaluation of 4,4’-Difluorobenzhydrol Carbamates as Selective M1 Antagonists. Pharmaceuticals (2022), 15(2), 248.110.3390/ph15020248
251. Miele, Margherita; Castoldi, Laura; Simeone, Xenia; Holzer, Wolfgang; Pace, Vittorio. Straightforward synthesis of bench-stable heteroatom-centered difluoromethylated entities via controlled nucleophilic transfer from activated TMSCHF2. Chemical Communications (2022), 58, 5761-5764. 10.1039/D2CC00886F
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